Advances in Diagnosis and Treatment of HPV Ocular Surface Infections

Editorial/no abstrac

A stochastic derivation of the geodesic rule

We argue that the geodesic rule, for global defects, is a consequence of the randomness of the values of the Goldstone field $\phi$ in each causally connected volume. As these volumes collide and coalescence, $\phi$ evolves by performing a random walk on the vacuum manifold $\mathcal{M}$. We derive a Fokker-Planck equation that describes the continuum limit of this process. Its fundamental solution is the heat kernel on $\mathcal{M}$, whose leading asymptotic behavior establishes the geodesic rule.Comment: 12 pages, No figures. To be published in Int. Jour. Mod. Phys.

Phase space measure concentration for an ideal gas

We point out that a special case of an ideal gas exhibits concentration of the volume of its phase space, which is a sphere, around its equator in the thermodynamic limit. The rate of approach to the thermodynamic limit is determined. Our argument relies on the spherical isoperimetric inequality of L\'{e}vy and Gromov.Comment: 15 pages, No figures, Accepted by Modern Physics Letters

Advances in Diagnosis and Treatment of HPV Ocular Surface Infections

Editorial/no abstrac

Eye and Periocular Skin Involvement in Herpes Zoster Infection

Herpes zoster ophthalmicus (HZO) is a clinical manifestation of the reactivation of latent varicella zoster virus (VZV) infection and is more common in people with diminished cell-mediated immunity. Lesions and pain correspond to the affected dermatomes, mostly in first or second trigeminal branch and progress from maculae, papules to vesicles and form pustules, and crusts. Complications are cutaneous, visceral, neurological, ocular, but the most debilitating is post-herpetic neuralgia. Herpes zoster ophthalmicus may affect all the ophthalmic structures, but most severe eye-threatening complications are panuveitis, acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN) as well. Antiviral medications remain the primary therapy, mainly useful in preventing ocular involvement when begun within 72 hours after the onset of the rash. Timely diagnosis and management of HZO are critical in limiting visual morbidity. Vaccine in adults over 60 was found to be highly effective to boost waning immunity what reduces both the burden of herpes zoster (HZ) disease and the incidence of post-herpetic neuralgia (PHN)

Rate of parity violation from measure concentration

We present a geometric argument determining the kinematic (phase-space) factor contributing to the relative rate at which degrees of freedom of one chirality come to dominate over degrees of freedom of opposite chirality, in models with parity violation. We rely on the measure concentration of a subset of a Euclidean cube which is controlled by an isoperimetric inequality. We provide an interpretation of this result in terms of ideas of Statistical Mechanics.Comment: 10 pages, no figure

An intelligent clinical information management support system for the critical care medical environment

Significant advances have been achieved in the fields of medical informatics and artificial intelligence in medicine in the past three decades and, having demonstrated an ability to support clinical decisions, knowledge-based systems are becoming increasingly ubiquitous in various clinical settings. Nonetheless, few systems have so far been successful in entering routine use. On the one hand, primarily due to methodological difficulties and with very few exceptions, developers have failed to show that pertinent systems are effective in improving patient care. On the other hand, support systems have not been sufficiently well integrated into the routine information processing activity of the clinical users. As a consequence, their clinical utility is disputed and constructive assessmenist further hindered. This thesis describes the development of an intelligent clinical information management support system designed to overcome these obstacles through the adoption of an integrated approach, geared toward the solution of the problems encountered in the acquisition, organisation, review and interpretation of the clinical decision supporting information utilised in the process of monitoring intensive care unit patients with acid-base balance disorders. The system was developed to support this activity incrementally, using the methods of object-oriented analysis, design and implementation, with the active participation of a clinical advisor who assessed the functional and ergonomic compatibility of the system with the supported activity and the integration of a previously validated prototype knowledge-based data interpretation system, which could not evaluated in the clinical setting for the reasons described above

Eye and Periocular Skin Involvement in Herpes Zoster Infection

Herpes zoster ophthalmicus (HZO) is a clinical manifestation of the reactivation of latent varicella zoster virus (VZV) infection and is more common in people with diminished cell-mediated immunity. Lesions and pain correspond to the affected dermatomes, mostly in first or second trigeminal branch and progress from maculae, papules to vesicles and form pustules, and crusts. Complications are cutaneous, visceral, neurological, ocular, but the most debilitating is post-herpetic neuralgia. Herpes zoster ophthalmicus may affect all the ophthalmic structures, but most severe eye-threatening complications are panuveitis, acute retinal necrosis (ARN) and progressive outer retinal necrosis (PORN) as well. Antiviral medications remain the primary therapy, mainly useful in preventing ocular involvement when begun within 72 hours after the onset of the rash. Timely diagnosis and management of HZO are critical in limiting visual morbidity. Vaccine in adults over 60 was found to be highly effective to boost waning immunity what reduces both the burden of herpes zoster (HZ) disease and the incidence of post-herpetic neuralgia (PHN)

Tsallis entropy approach to radiotherapy treatments

The biological effect of one single radiation dose on a living tissue has been described by several radiobiological models. However, the fractionated radiotherapy requires to account for a new magnitude: time. In this paper we explore the biological consequences posed by the mathematical prolongation of a model to fractionated treatment. Nonextensive composition rules are introduced to obtain the survival fraction and equivalent physical dose in terms of a time dependent factor describing the tissue trend towards recovering its radioresistance (a kind of repair coefficient). Interesting (known and new) behaviors are described regarding the effectiveness of the treatment which is shown to be fundamentally bound to this factor. The continuous limit, applicable to brachytherapy, is also analyzed in the framework of nonextensive calculus. Also here a coefficient arises that rules the time behavior. All the results are discussed in terms of the clinical evidence and their major implications are highlighted.Comment: 6 figures, accepted for publication to Physica